40年后的未来，新冠疫情似乎已经快要结束了。斯坦·马什从南方公园搬到了城市里，他现在的工作是线上威士忌咨询师。他正在“工作”时，他的亚莉克莎化成全息影像来提醒他，凯尔·布罗夫洛夫斯基来电话了。而自从四人组关系破裂后，斯坦和凯尔便没有再说过话。在电话中，凯尔叫斯坦回南方公园来看看，斯坦拒绝了，说那里已经没有什么值得他留恋的东西了。凯尔便告诉他，肯尼·麦考密克死了。之后，吉米·瓦尔莫在纽约录制他的节目《吉米深夜秀》（Late Night With Jimmy）时，突然得知了著名怪人科学家、百万富翁慈善家肯尼·麦考密克死亡的消息。于是，他立即决定订机票返回南方公园参加葬礼。
肯尼的守灵会由吉米主持，几乎所有的四年级同班同学都来参加了。其中有温蒂·泰斯伯格和她的丈夫达尔文，依然在一起的特维克·特威克和克雷格·塔克，还有克莱德·多诺万，他们都是从市里赶来的。他们都说疫情改变了很多东西，并对肯尼的真正死因表示怀疑。斯坦、凯尔还见到了埃里克·卡特曼，他已经皈依犹太教，还在科罗拉多斯普林斯成了一名拉比。他说，They also meet Eric Cartman, who has converted to Judaism and become a rabbi in Colorado Springs, citing the pandemic as having changed him, and is married to a Jewish woman named Yentil, and explains he and Kenny remained in contact, and Kenny's mission was trying to find the origin of the coronavirus. Kyle continues to insist this is all an act purely to upset him, even over forty years, but he and Stan see Cartman hugging his two children as he leaves. Back at the motel, Stan sees another clip of Kenny, where one of his math equations contains a reference to Tegridy Weed which unsettles him, as he does not want to face his father.
Stan arrives at the funeral in South Park Church to find it is being lead by Scott Malkinson, who has become a Priest, though nobody seems to want to acknowledge him. Scott tells a euology urgering churchgoers to reflect and to cherish friends and family, and out of guilt Stan lashes out and asks Kyle if he wrote the speech, and admits that he knows something about Kenny he cannot admit since it relates to his father, who he doesn't want to face. The three boys argue in church before Stan storms out and promises to leave town, mocking Scott like they did when they were kids. Rabbi Cartman takes over the euology, but is interrupted by a doctor who announces that the cause of Kenny's death was COVID Delta Plus Rewards program variant, causing chaos as the townspeople flee for supplies and "chin diapers", running out of supplies in moments. The military arrives and closes the roads to contain the outbreak, preventing Stan, Cartman, or anyone from leaving, as there is an individual in the town who is not vaccinated, whom they refuse to name. They are heavily armed and shoot an individual who tries to leave.
South Park Elementary Plus is set up as an emergency shelter for out-of-town visitors, presided over by an aged PC Principal, who orders lights out at nine o' clock. Token, Clyde, Jimmy, Craig, Tweek and Wendy discuss these events and suspect that Kenny's Covid diagnosis is a coverup to hide Kenny's research, pointing out they are all vaccinated. Clyde remarks that it is a "personal choice" and they mock him for not being vaccinated, pointing out there is now forty years of research. Alexa, meanwhile, urges Stan to visit his father if there is a chance he could help his friends, mocking him for his repeated refusal to do so. The shelter fills up, however, forcing Cartman, his wife, and three children to turn to Kyle, hoping to stay at the Broflovski Residence, as it is a "nice Jewish home", asking his kids to refer to him as "Uncle Kyle". When Kyle overhears Cartman having sex with his wife and mentioning stories from the Torah, he interrupts them in the middle of the night and believes this is part of the ruse to upset him, informing Yentil that Cartman had previously snuck into his room and gave him AIDS. Cartman promises his family will leave in the morning, despite the protess of his children.
The next morning, Jimmy, Craig, Tweek, Wendy and Darwin try to ask Clyde to take the vaccine so they may return home, but he says he has an allergy to shellfish and the vaccine is sometimes cross-contaminated with 'shellfishness' and that his refusal is based on a general sense of "shellfishness". Token then draws their attention to the McCormick Science Wing of the school, where they discovery a massive secret laboratory splattered in blood, and much of his research. They discover that a man named Victor Chaos (pronounced 'Chowce') is mentioned throughout Kenny's research as a right-hand man, is now being kept at the South Park Mental Asylum Plus, but he cannot take phone calls and they can only see him if the entire party is vaccinated, which Clyde still is not. Wendy approaches Clyde suggesting they "party" and pretending to do cocaine, but when Clyde realizes the cocaine is the vaccine, he refuses to inject into his body. Back at the Broflovski Residence, the Cartman family are leaving and Kyle apologizes and asks them to stay, though he is clearly uncomfortable. Token arrives with Kenny's research, and he and Kyle realize that Kenny compiled years of research into time travel, intending to prevent the pandemic entirely. When Kyle is distracted by Cartman and Yentil kissing and whispering to each other, however, their children begin to insult "Uncle Kyle" and admit he drives them crazy, behaving similarly to their father had as a child. Token mentions that Kenny said they would have to "think like kids" and realizes that the secret is in Kenny's ass.
来到节草农场被烧毁的遗迹，兰迪将责任追溯到加里森当选总统、新冠疫情、未指明的种族战争以及电影《空中大灌篮2》（Space Jam 2）的上映。他声称由于中国的影响，世界 "失去了节操"，中国想通过让所有人失去积极乐观的精神，以此成为一个超级大国来削弱美国。兰迪承认他和穿山甲发生了关系然后引发了新冠疫情。他声称是中国利用了他。兰迪透露他创造并珍藏了一种促销型节草大麻来拯救大家。当他们打开柜子后发现藏起来的大麻不见了，地上新鲜的脚印表明它最近才被偷走。除了被盗走的这些大麻，兰迪还在屁眼里藏了一些种子，但在老人院时种子也被拿走了。斯坦也因此想到了肯尼藏重要信息的地方。兰迪看到了莎伦和雪莉的鬼魂，她们指责斯坦对火灾的责任。然后他发现了一株最后幸存的节草嫩芽，并开始保护它。